Yeh TF, Pildes RS "Transplacental aminophylline toxicity in a neonate. Do not administer this drug by intramuscular, subcutaneous, intrathecal, or intraperitoneal injection. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Many drugs can interact with theophylline and not all possible interactions are listed in this medication guide. Clearance represents the volume of blood completely cleared of theophylline by the liver in one minute.
Theophylline is structurally classified as a methylxanthine. This may not be a complete list of all interactions that may occur. Ask your health care provider if Quibron-T may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Dose is based on body weight and must be determined by your doctor. At first, the dose is 12 to 14 milligrams mg per kg of body weight per day as a single dose, usually in the morning, or divided and given two times per day. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day.
Get medical help right away if your asthma symptoms worsen or if you are using your quick-relief inhaler more than usual or more often than prescribed. Decreases theophylline clearance by inhibiting cytochrome P450 1A2. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Careful monitoring of side effects and drug blood levels is recommended. Arwood LL, Dasta JF, Friedman C "Placental transfer of theophylline: two case reports. Sur la base de la réponse et de la tolérance peut être administré trois fois par jour. Administrer une fois par jour au coucher. Increases theophylline clearance by induction of microsomal enzyme activity. If the serum sample is drawn more than two hours after the dose, the results must be interpretedwith caution since the concentration may not be reflective of the peak concentration. In contrast, when signs or symptoms of theophylline toxicity are present, the serum sample should be obtained as soon as possible, analyzed immediately, and the result reported to the clinician without delay.
Frederiksen MC, Ruo TI, Chow MJ, Atkinson AJ, Jr "Theophylline pharmacokinetics in pregnancy. Due to the immaturity of theophylline metabolic pathways in infants under the age of one year, particular attention to dosage selection and frequent monitoring of serum theophylline concentrations are required when theophylline is prescribed to pediatric patients in this age group. Safety and efficacy of this drug has not been established; its limited use in pediatric patients has been inadequate to fully define the proper dosage and limitations of use. Available data suggests that drug administration at the time of food ingestion may influence the absorption characteristics if some or all theophylline controlled-release products, resulting in serum values different from those found after administration in the fasting state. Not reported in a comparable manner. Monitor patients for approximately one week after treatment cessation of caffeine citrate due to risk of apnea recurrence. Each of the aliquots was administered with the patient in one of four different positions prone, supine, right, and left lateral.
Swallow the pill whole. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. The chronicity and pattern of theophylline overdosage significantly influences clinical manifestations of toxicity, management and outcome. The most common causes of chronic theophylline overdosage include patient or care giver error in dosing, clinician prescribing of an excessive dose or a normal dose in the presence of factors known to decrease the rate of theophylline clearance, and increasing the dose in response to an exacerbation of symptoms without first measuring the serum theophylline concentration to determine whether a dose increase is safe. Manufactured by: ONY, Inc. Amherst, NY 14228 Rev. These observations were not associated with increased mortality. The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the “Effect” column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. bicalutamide
FDA pregnancy category C. It is not known whether theophylline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. F. PROTECT FROM LIGHT STORE UPRIGHT SWIRL GENTLY TO RESUSPEND BEFORE USE SINGLE USE VIAL: DICARD UNUSED PORTION. Dosage: 3 mL of Infasurf per kg of body weight. Safety and efficacy have not been established in patients younger than 18 years. Transient caffeine-like adverse effects and excessive serum concentrations in slow metabolizers can be avoided in most patients by starting with a sufficiently low dose and slowly increasing the dose, if judged to be clinically indicated, in small increments See . Dose increases should only be made if the previous dosage is well tolerated and at intervals of no less than 3 days to allow serum theophylline concentrations to reach the new steady state. The information contained in the Truven Health Micromedex products as delivered by Drugs. Serum theophylline concentrations may continue to increase after presentation of the patient for medical care as a result of continued absorption of theophylline from the gastrointestinal tract. Serial monitoring of serum theophylline serum concentrations should be continued until it is clear that the concentration is no longer rising and has returned to non-toxic levels. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. The brand name Uniphyl is discontinued, but versions may be available. The listing of drugs in Tables II and III are current as of October 8, 1996. New interactions are continuously being reported for theophylline, especially with new chemical entities. bema.info dilantin
Patients should be instructed to take this medication each morning at approximately the same time and not to exceed the prescribed dose. The dose must be determined by your doctor. However, the total dose is usually not more than 400 milligrams per day, divided and given every 6 to 8 hours. During administration of Infasurf liquid suspension into the airway, infants often experience bradycardia, reflux of Infasurf into the endotracheal tube, airway obstruction, cyanosis, dislodgement of the endotracheal tube, or hypoventilation. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Do not start or stop smoking without first talking to your doctor. Smoking changes the way your body uses theophylline, and you may need to use a different dose. Lithium dose required to achieve a therapeutic serum concentration increased an average of 60%. Treatment of seizures Because of the high morbidity and mortality associated with theophylline-induced seizures, treatment should be rapid and aggressive. Distribution Once theophylline enters the systemic circulation, about 40% is bound to plasma protein, primarily albumin. Unbound theophylline distributes throughout body water, but distributes poorly into body fat. Some MEDICINES MAY INTERACT with Quibron. Infasurf as measured on a pulsating bubble surfactometer. Ex vivo, Infasurf restores the pressure volume mechanics and compliance of surfactant-deficient rat lungs. In vivo, Infasurf improves lung compliance, respiratory gas exchange, and survival in preterm lambs with profound surfactant deficiency. Dose is based on body weight and must be determined by your doctor. At first, the dose is 12 to 14 milligrams mg per kg of body weight per day, divided and given every 12 hours. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day. Extended-release capsules meet Drug Release Test 6 as published in the current USP monograph for Theophylline Extended-release Capsules. Administration of Infasurf for prophylaxis should be given as soon as possible after birth. Infasurf therapy is indicated for infants less than or equal to 72 hours of age with RDS confirmed by clinical and radiologic findings and requiring endotracheal intubation. What other drugs will affect theophylline Theo-24? WARNINGS or if it is not feasible to monitor serum theophylline concentrations. arava pharmacy bangkok
Ask your healthcare professional how you should dispose of any medicine you do not use. Treatment Duration: Safety and efficacy of this drug for treatment of apnea of prematurity have not been established beyond 12 days. Pediatrics The clearance of theophylline is very low in neonates see . Theophylline clearance reaches maximal values by one year of age, remains relatively constant until about 9 years of age and then slowly decreases by approximately 50% to adult values at about age 16. Renal excretion of unchanged theophylline in neonates amounts to about 50% of the dose, compared to about 10% in children older than three months and in adults. At steady state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean theophylline half-life of 8 hours. The difference between peak and trough concentrations is larger in patients with more rapid theophylline clearance. In patients with high theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum theophylline concentration may be only 30% of peak with a 6-hour dosing interval. Store vials in carton until time of use; protect from light.
Store at room temperature away from moisture, heat, and light. Follow the directions on your prescription label. Use and dose must be determined by your doctor. Progrs thrapeutique mineur par comparaison aux Autres insulines l'essentiel LANTUS insuline glargine is a insulino daction lente Indique, partir de 6 ans, DANS LE treatment du diabte sucr ncessitant non treatment par insuline. Dans le diabte de type 1, les analogues et Rapides carêmes de linsuline, ne pas linsuline glargine, Ont contribu faire du Schma basal-bolus le Schma dadministration de rfrence. Dans le diabte de type 2, lorsquune insulinothrapie is Indique, il ny a pas dargument clinic verser privilgier analogique non prêté de linsuline par rapport aux insulines NPH, Qué this Soit en Termes de Contrle glycmique ous de tolrance. LANTUS un permis juin: réduction modeste des hypoglycmies nocturnes Mais la qualit de vie des patients pas de napparat amliore. LANTUS les exposerait patients Moins dhypoglycmies nocturnes quune insulino daction intermdiaire NPH la taille de CET effet impor-, au mieux, modeste. Stratgie thrapeutique Les Objectifs de la prise en charges du diabte are de rduire la morbi-mortalit Associe et de prserver la qualit de vie. Lducation thrapeutique is indispensable. Elle is also très utile versez le decrease osée hypoglycmique. Dans le diabte de Type 1. les patients doivent bnficier dune insulinothrapie et dune prix en accusation nutritionnelle. Les Objectifs du treatment are. Le Contrle De La glycmie versez prvenir les complications à long terme est la microangiopathie diabtique, la prvention des hypoglycmies et de lacidoctose et, chez lenfant, la prvention du retentissement sur le dveloppement staturo-pondral et pubertaire. La mise disposition danalogues carêmes de linsuline insuline glargine et dtmir utiliss SELON UN Schma basal-bolus, including en association with a analogique rapide de linsuline, un juin de constitu avance in the prize en charge de le CES patients. LANTUS may tre prescribed in the cadre dun Schma dinsulinothrapie nominale multi-injections de type de débit basal-bolus. Dans le diabte de Type 2. le treatment initial repos sur lvaluation et la modification raliste des habitudes de vie alimentation et activit physique. La lutte actif contre la sdentarit AINSI Que la planification des interventions alimentaire reprsentent irremplaables Toutes Les bandes de la prise en charges. Linsulinothrapie sajoutant aux Measures hygino-dittiques, MHD may tre commencer chez les patients adultes lassociation with les glitazones impor - Alors contre-Indique: when le Taux dHbA1c is when le Taux dHbA1c is 8 malgr 6 ou de mois, plus dune trithrapie. En Cas dadjonction dune insuline juin bithrapie orale, il is recommand de faire une injection unique, au coucher dune insuline daction intermdiaire NPH OÜ isabelle analogique prêté insuline glargine ous dtmir dexnatide UO BYETTA injectable en CAS dexcs pondral. En Cas dchec, juin insulinothrapie tre intensifie Doït mise en uvre. Donnes Cliniques Efficacit in the diabte de Type 1: Chez ladulte. Dans le cadre dun Schma dinsulinothrapie par multi-injections de Type basal-bolus, les donnes confirment that the Contrle glycmique Obtenu SELON le Taux dHbA1c avec insuline glargine is comparable with Celui Obtenu insulino NPH. Overdose symptoms may include severe forms of some of the side effects listed in this medication guide. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Theophylline has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryolethality and teratogenicity. There are no controlled data in human pregnancy. Theophylline is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk. Monitor the patient and obtain a serum theophylline concentration in 2-4 hours to insure that the concentration is not increasing. Table V. Dosing initiation and titration as anhydrous theophylline. Horowitz DA, Jablonski W, Mehta KA "Apnea associated with theophylline withdrawal in a term neonate. Have had a fever of 102 degrees F or higher for at least 24 hours or more. Phone: 800 477-7877, Fax: 770 970-8859. Manufactured for: UCB Pharma, Inc. Increasing the rate of theophylline clearance by extracorporeal methods may rapidly decrease serum concentrations, but the risks of the procedure must be weighed against the potential benefit. Inactive Ingredient: magnesium stearate. purchase generic motilium visa usa
There are no adequate and well-controlled studies in pregnant women. Note: Serum theophylline concentrations may continue to increase after presentation of the patient for medical care. The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Table V contains theophylline dosing titration schema recommended for patients in various age groups and clinical circumstances. Table VI contains recommendations for theophylline dosage adjustment based upon serum theophylline concentrations. Application of these general dosing recommendations to individual patients must take into account the unique clinical characteristics of each patient. In general, these recommendations should serve as the upper limit for dosage adjustments in order to decrease the risk of potentially serious adverse events associated with unexpected large increases in serum theophylline concentration. Table V. Dosing initiation and titration as anhydrous theophylline. What should I discuss with my healthcare provider before taking theophylline Theo-24? Hemodialysis should be considered as an alternative when charcoal hemoperfusion is not feasible and multiple-dose oral charcoal is ineffective because of intractable emesis. What other drugs will affect Quibron guaifenesin and theophylline? How should I take theophylline Theo-24? Do not use this medication without telling your doctor if you are breast-feeding a baby. FDA pregnancy category C. This medication may be harmful to an unborn baby. caverta money order mastercard uk
What should I avoid while taking Quibron-T theophylline? Consult a healthcare provider if your baby continues to have apnea events; do not increase the dose of caffeine citrate without medical consultation. Take this medication by mouth with or without food, usually once or twice daily or as directed by your doctor. If this medication upsets your stomach, you may take it with food. This medicine works best when the amount in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals. Since different manufacturers have different recommendations, check with your doctor or pharmacist about the best times to take your particular brand of theophylline. For most patients, steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Guaifenesin and theophylline can pass into breast milk and may harm a nursing baby. Avoid eating foods that are high in fat within 1 hour before or after taking theophylline. This may not be a complete list of all interactions that may occur. Ask your health care provider if Quibron may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. The dose must be determined by your doctor. However, the total dose is usually not more than 400 milligrams per day as a single dose, usually in the morning, or divided and given two times per day. An inhaled beta-2 selective agonist, alone or in combination with a systemically administered corticosteroid, is the most effective treatment for acute exacerbations of reversible airways obstruction. Theophylline is a relatively weak bronchodilator, is less effective than an inhaled beta-2 selective agonist and provides no added benefit in the treatment of acute bronchospasm. If an inhaled or parenteral beta agonist is not available, a loading dose of an oral immediate release theophylline can be used as a temporary measure. MTX, higher dose MTX may have a greater effect. Infasurf calfactant Intratracheal Suspension is supplied sterile in single-use, rubber-stoppered glass vials containing 3 mL NDC 61938-456-03 and 6 mL NDC 61938-456-06 off-white suspension. Serum theophylline concentration measurements are readily available and should be used to determine whether the dosage is appropriate. Charcoal must be retained in, and pass through, the gastrointestinal tract to be effective; emesis should therefore be controlled by administration of appropriate antiemetics. Alternatively, the charcoal can be administered continuously through a nasogastric tube in conjunction with appropriate antiemetics. A single dose of sorbitol may be administered with the activated charcoal to promote stooling to facilitate clearance of the adsorbed theophylline from the gastrointestinal tract. Sorbitol alone does not enhance clearance of theophylline and should be dosed with caution to prevent excessive stooling which can result in severe fluid and electrolyte imbalances. Commercially available fixed combinations of liquid charcoal and sorbitol should be avoided in young children and after the first dose in adolescents and adults since they do not allow for individualization of charcoal and sorbitol dosing. Treat overdose as indicated see recommendations for chronic overdosage. If theophylline is subsequently resumed, decrease dose by at least 50% and recheck serum concentration after 3 days to guide further dosage adjustment. Beta-2 blocking effect may decrease efficacy of theophylline. cyclosporin
Severe toxicity from theophylline overdose is a relatively rare event. In one health maintenance organization, the frequency of hospital admissions for chronic overdosage of theophylline was about 1 per 1000 person-years exposure. There are several readily identifiable causes of reduced theophylline clearance. If you miss a dose of Quibron, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. This medication can cause side effects that may impair your thinking or reactions. If symptoms are not controlled and current dosage is tolerated, increase dose about 25%. Recheck serum concentration after three days for further dosage adjustment. If you miss a dose, skip the missed dose. Take your next dose at the regular time. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Children 6-15 years and adults 16-60 years without risk factors for impaired clearance. If you have more than one doctor, be sure to tell each of your doctors that you are taking Quibron.
Disclaimer: Every effort has been made to ensure that the information provided by Multum, Truven Health Analytics, Inc. Smyrna, GA 30080. by Pfizer Pharmaceuticals LLC Caguas, PR 00725. Serious adverse effects in the infant are unlikely unless the mother has toxic serum theophylline concentrations. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. THE ADMINISTRATION OF EXOGENOUS SURFACTANTS, INCLUDING Infasurf, OFTEN RAPIDLY IMPROVES OXY GENATION AND LUNG COMPLIANCE. Following administration of Infasurf, patients should be carefully monitored so that oxygen therapy and ventilatory support can be modified in response to changes in respiratory status. Infasurf therapy is not a substitute for neonatal intensive care. Optimal care of premature infants at risk for RDS and new born infants with RDS who need endotracheal intubation requires an acute care unit organized, staffed, equipped, and experienced with intubation, ventilator management, and general care of these patients. Diabetes patients - Quibron may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Once theophylline enters the systemic circulation, about 40% is bound to plasma protein, primarily albumin. Unbound theophylline distributes throughout body water, but distributes poorly into body fat. Always consult a healthcare professional for medical advice. truvada tv
Dosing Guidelines, Table VI. Caffeine may increase some of the side effects of theophylline. Increased frequency of nausea, nervousness, and insomnia. Quibron is a combination xanthine derivative and expectorant. The xanthine derivative works by relaxing the smooth muscle surrounding the bronchial tubes air passages of the lungs, allowing the tubes to widen, and making breathing easier. Quibron improves contraction of the diaphragm the major breathing muscle. The expectorant works by increasing respiratory secretions and loosening mucus in the airways. If symptoms are not controlled and current dosage is tolerated, increase dose about 25%. Theophylline is used to treat lung diseases such as asthma and COPD bronchitis, emphysema. It must be used regularly to prevent wheezing and shortness of breath. This medication belongs to a class of drugs known as xanthines. It works in the airways by relaxing muscles, opening breathing passages, and decreasing the lungs' response to irritants. Controlling symptoms of breathing problems can decrease time lost from work or school. Dombrowski MP "Pharmacologic therapy of asthma during pregnancy. Take the missed dose as soon as you remember. Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter. If you do not have a dose-measuring device, ask your pharmacist for one. Product Information. Theo-Dur theophylline. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. After you or your child begin taking theophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. Keep all appointments for testing the blood level. brand iressa royal
For various North American patient populations from literature reports. Different rates of elimination and consequent dosage requirements have been observed among other peoples. Before making a dose increase to determine whether the serum concentration is sub-therapeutic in a patient who continues to be symptomatic. Theophylline overdose can occur if you accidentally take too much at one time. Overdose can also occur slowly over time if your daily doses are too high. To be sure you are using the correct dose, your blood will need to be tested often. Theophylline passes freely across the placenta, into and into the cerebrospinal fluid CSF. Saliva theophylline concentrations approximate unbound serum concentrations, but are not reliable for routine or therapeutic monitoring unless special techniques are used. An increase in the volume of distribution of theophylline, primarily due to reduction in plasma protein binding, occurs in premature neonates, patients with hepatic cirrhosis, uncorrected acidemia, the elderly and in women during the third trimester of pregnancy. Serum theophylline and phenytoin concentrations decrease about 40%. The dose must be determined by your doctor. However, the total dose is usually not more than 400 milligrams per day, divided and given every 12 hours. Do not take more than the recommended dose or use more often than prescribed without checking with your doctor. If your symptoms become worse, contact your doctor. While simultaneously instituting treatment, contact a regional poison center to obtain updated information and advice on individualizing the recommendations that follow. Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; if you start or stop smoking cigarettes or marijuana; or if another doctor prescribes a new medication or tells you to stop using a medication that you have already been taking. You may take theophylline with or without food, but take it the same way every time. Increases theophylline clearance by increasing demethylation and hydroxylation. Decreases renal clearance of theophylline. Whenever signs or symptoms of theophylline toxicity are present. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Stenius-aarniala B, Riikonen S, Teramo K "Slow-release theophylline in pregnant asthmatics. IV over 30 minutes one time. pletal
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If the serum sample is drawn more or less than twelve 12 hours after the dose, the results must be interpreted with caution since the concentration may not be reflective of the peak concentration. Infasurf DOES NOT REQUIRE RECONSTITUTION. DO NOT DILUTE OR SONICATE. Monitor the patient and obtain serial theophylline concentrations every 2-4 hours to gauge the effectiveness of therapy and to guide further treatment decisions. Theophylline has been studied in Ames salmonella, in vivo and in vitro cytogenetics, micronucleus and Chinese hamster ovary test systems and has not been shown to be genotoxic.
The dosage is based on your medical condition, response to treatment, age, weight, lab tests theophylline blood levels and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Theophylline increases the force of contraction of diaphragmatic muscles. This action appears to be due to enhancement of calcium uptake through an adenosine-mediated channel.
Check with your pharmacist about how to dispose of unused medicine. Consider 10% decrease in dose to provide greater margin of safety even if current dosage is tolerated. Enhance clearance of theophylline.
In selected patients at high risk for theophylline-induced seizures, consideration should be given to the administration of prophylactic anticonvulsant therapy. Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden breathing problems. If sudden shortness of breath occurs, use your quick-relief as prescribed.